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RESEARCH ARTICLE

Artificial Intelligence in Dermatology: Assessing Predictability in Clinical Diagnosis

The Open Dermatology Journal 02 Sept 2025 RESEARCH ARTICLE DOI: 10.2174/0118743722410124250901081508

Abstract

Introduction

The use of Artificial Intelligence (AI) for image-based diagnosis in dermatology is increasing rapidly. The clinical accuracy of AI in diagnosing different skin conditions remains under evaluation. This study aimed to evaluate the diagnostic performance of an AI application in comparison to confirmed clinical diagnoses by dermatologists.

Method

A cross-sectional study was carried out on 400 patients with different skin conditions, including acne, alopecia, eczema, pigmentary disorders, psoriasis, immunological disorders, tumors, infections, and infestations. The study analyzed AI-based predictions using the Tibot AI application, comparing them against dermatologists’ diagnoses.

Results

The AI application demonstrated high diagnostic accuracy for certain dermatological conditions such as adnexal disorders (AUC 0.93–0.98), pigmentary disorders (AUC 0.88–0.94), and cutaneous tumors (AUC 0.87–0.95). Sensitivity for adnexal disorders was 88.9% (top one) and 94.4% (top three), and for Pigmentary disorders, it was 75.8% and 87.9% for top one and top-three predictions, respectively.

However, AI performance was lower for immunological disorders (31.3% sensitivity) and cutaneous infestations (22.2%). Overall accuracy improved across all conditions when considering the top-three predictions.

Discussion

Tibot AI-application demonstrated high diagnostic accuracy for conditions with distinct morphological features such as adnexal, pigmentary disorders, and cutaneous tumors. It showed lower sensitivity for immunological disorders and infestations, indicating the need for further AI training with more diverse datasets.

Conclusion

AI-based diagnostic accuracy improved significantly when considering the top-three diagnoses, indicating its value as a differential diagnostic tool. It showed promising accuracy in adnexal, pigmentary disorders, and cutaneous tumors. However, it is less robust for immunological skin diseases and infections, highlighting the need for further refinement.

Keywords: Artificial Intelligence, Deep learning, Machine learning, Dermatology, Adnexal disorders, Pigmentary disorders.
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